Exciting research news from the University of Birmingham suggests that giving progesterone to pregnant women with early pregnancy bleeding and a history of miscarriage could increase live births.
The PRISM trial, co-ordinated by Birmingham Clinical Trials Unit in collaboration with Tommy’s National Centre for Miscarriage Research, involved 4153 pregnant women who presented with early pregnancy bleeding.
Miscarriage affects one in five women and bleeding in early pregnancy is linked to a one in three risk of miscarriage.
This largest ever trial of its kind was undertaken to answer a very important research question; whether progesterone given to pregnant women with threatened miscarriage would increase the number of babies born after at least 34 weeks of gestation compared to placebo.
It is important to note that results did not suggest that progesterone could help ALL women who are suffering early pregnancy bleeding to have a live birth, however, it did show that it benefitted those who had early pregnancy bleeding and had a previous miscarriage.
The ground-breaking research was published today in the New England Journal of Medicine and you can read more about it all here
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